Cheetah
Cheetah3D version 3.0 for Mac OS X is able to generate EPix files ready for use by Piranesi. Before rendering, go to Render Preferences and select the 'cache EPIX' box.
When rendered to your satisfaction, save the image with a .epx extension.
You can download a tutorial on using Cheetah3D with Piranesi from the Cheetah3D website.